Chunshan gui and oatp1b1
WebFeb 8, 2008 · Chunshan Gui, a Yi Miao, a Lucas Thompson, a Bret Wahlgren, a Melissa Mock, b Bruno Stieger, b and Bruno Hagenbuch a, c ... transport, we developed Chinese Hamster Ovary (CHO) cell lines stably expressing OATP1B1 or 1B3 at high levels. OATP1B1- and 1B3-mediated estradiol-17β-glucuronide uptake was inhibited by several … WebDec 16, 2024 · OATP1B1, OATP1B3, and OATP2B1, with OATP1B3 showing the highest transport efficiency. The Kmvalues for OATP1B1-, OATP1B3-, and OATP2B1-mediated PSP uptake were 11.3 ± 1.5, 7.0 ±1.5, and 5.1 ±1.0...
Chunshan gui and oatp1b1
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WebSep 2, 2008 · Three-dimensional model of the OATP1B3/CCK-8 complex. A side view (A) and a view from the intracellular side (B) are presented. Helical segments of the protein are shown in cylinders; the three residues Y537, S545 and T550 in TM10 are shown in ball-and-stick and in orange; CCK-8 is shown in ball-and-stick and in purple. WebMar 1, 2024 · OATP1B1 has broad substrate specificity and the structures of its substrates/inhibitors are quite diverse (Hagenbuch and Gui, 2008). With the increasing number of structurally diverse substrates/inhibitors for OATP1B1, it’s almost impossible to reliably superimpose hundreds of these molecules to carry out 3D-QSAR analysis.
WebAbstract: The two organic anion transporting polypeptides (OATPs) 1B1 and 1B3 are expressed at the sinusoidal membrane of hepatocytes. They have a broad and overlapping substrate specificity and transport many endobiotics and drugs. WebIn this study, we investigated the molecular mechanism for this substrate selectivity of OATP1B1 by constructing OATP1B1/1B3 chimeric transporters and by site-directed …
WebAug 6, 2024 · A number of drug-drug and drug-food interactions have been associated with OATP1B1 and 1B3, affecting the pharmacokinetics and pharmacodynamics of their substrate drugs. 8–16 It has also been reported that many natural substances present in food or dietary supplements such as flavonoids could intact with OATP1B1 and 1B3 and … WebIdentification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport …
WebJun 30, 2011 · Chunshan Gui et al. have confirmed that ursolic acid is a selective OATP1B3 and OATP1B1 inhibitor (Chunshan et al. 2010 ). Therefore, there may be an interaction between ursolic acid and rosuvastatin. A reasonable combination use of rosuvastatin and herbal medicines containing ursolic acid has important clinical value.
WebThis type of analysis has been previously successfully used to determine the type of interaction of OATP1B1 with a wide range of physiological substrates and fibrates (Gui et al., 2009; Yamazaki ... cyro color chartWebDec 24, 2024 · Taken together with our previous results 7 that the mutations of OATP1B1*5, *15 and CYP2C9*2, *3 significantly affect the transport and metabolism of glimepiride … binaxnow covid ag card global point of careWebJan 1, 2024 · Chunshan Gui Organic anion transporting polypeptide 1B1 (OATP1B1) is a key hepatic uptake transporter whose inhibition could lead to adverse drug-drug and drug-food interactions. binaxnow covid-19 self test kitWebChunshan Gui1, Amanda Obaidat1, Rathnam Chaguturu2,3 and Bruno Hagenbuch*,1,2 ... hibitors for OATP1B1 and OATP1B3. We have used OATP1B1- or OATP1B3-expressing Chinese Hamster Ovary cells ... 2010, Volume 4 Gui et al. used this assay to screen the Prestwick library for modulators (inhibitors or stimulators) and confirmed several hits by binaxnow covid ag testWebNov 1, 2009 · Search worldwide, life-sciences literature Search. Advanced Search cyro bank of americaWebAug 9, 2008 · Human organic anion transporting polypeptides (OATP) 1B1 and 1B3 are multispecific transporters that mediate uptake of amphipathic organic compounds into hepatocytes. The two OATPs contain 12 transmembrane domains (TMs) and share 80% amino acid sequence identity. binaxnow covid 19 test antigen self testWebIdentification, Kidetermination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide transport Chunshan Guia, Brett Wahlgrena, Gerald H. Lushingtonb, and Bruno Hagenbucha,c,* cyro currency market